Present in Dendrobiurn nobile, this alkaloid forms colourless crystals from
MeOH. It yields a crystalline hydrochloride, m.p. 206-8°C and the methiodide,
m.p. 275-6°C. Treatment of the free base with alcoholic KOH followed by HCI
gives isonobiline hydrochloride, m.p. l83-5°C. LiAIH4 furnishes an amorphous
tril whereas NaBH4 in tetrahydrofuran gives the amorphous hydroxynobiline
which is converted into hydroxyisonobiline, m.p. 217 -9°C under the same
conditions as given above for the alkaloid. Hofmann degradation of nobiline
methiodide yields trimethylamine and deaminonobiline, m.p. l79-183°C. The
structure given above for the alkaloid has been suggested on the basis of these
chemical reactions and spectroscopic evidence.
Yamamura, Hirata., Tetrahedron Lett., 79 (1964)