A further alkaloid from Vinca rosea L., forming colourless prisms when crystallized from MeOH. The ultraviolet spectrum has absorption maxima at 230, 293
and 328 mil. The base contains a tertiary hydroxyl group and an imino group
and, with AC20 in pyridine, furnishes akuammicine (q.v.), by dehydration.
Reduction with Zn dust in MeOH-H2S04 yields 2: 16-dihydroakuammicine after
preparative thin-layer chromatography on silica gel.
Svoboda et al., J. Pharm. Sci., 50, 409 (1961)
Structure:
Nakagawa et at., Chem. Ind., 1986 (1962)
