Anti-G/T Mismatch-binding protein, Anti-GTBP, Anti-HNPCC5, Anti-mutS (E. coli) homolog 6, Anti-Colorectal cancer, hereditary noopolyposis, type 5, included

Anti-MSH6 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

MutS Homolog 6 (MSH6) is localized on human chromosome 2p16.3. MSH6 is a 160 kDa protein with nuclear localization sequence and a N-terminal disordered domain. It is a human homolog of E. coli MutS.

MSH6 (also known as GTBP) was isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of MSH2-deficient colorectal tumor cell lines. MutS Homolog 6 (MSH6) is part ofDNA repair pathways and play a key role onmutator S protein (hMutSα) shuttling. MSH6 has ATPase activity that is critical in mismatch repair. Germline mutations in MSH6 is associated with hereditary nonpolyposis colon cancer and in endometrial carcinoma.