NOTCH homolog-1 (NOTCH-1) is a transmembrane receptor.
Biochem/physiol Actions
NOTCH homolog-1 (NOTCH-1) is an integral part of the NOTCH signaling pathway, which regulates various cellular functions. NOTCH-1 enhances the invasion of cancer cells and mutations in the gene encoding it have been associated with chronic lymphocytic leukemia (CLL).
