Starburst(R) (PAMAM) dendrimer, generation 2.5

PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is used as a compacting agent to bring in the conformational changes in the DNA molecule. It can be attached on the cellulose substrate that acts as a biofunctional surface for potential applications in immonoassays. It is used in MRI contrast agents and in the condensation formation of silica nanospheres.

PAMAM dendrimer, ethylenediamine core, generation 4.0 solution is a poly(amidoamine) that is categorized as a class of dendritic polymers which can be prepared by a two-step interactive reaction that forms generations around the central ethylenediamine core. It consists of nitrogen and amide as functional groups that are structured in regular “branched upon branched” pattern. It is majorly used as a high capacity chelating agent.

[1] TISHA C. KING HEIDEN . Developmental toxicity of low generation PAMAM dendrimers in zebrafish[J]. Toxicology and applied pharmacology, 2007, 225 1: Pages 70-79. DOI: 10.1016/j.taap.2007.07.009
[2] ASGHAR NARMANI  Javad M  Kamal Yavari. Imaging, biodistribution and in vitro study of smart 99mTc-PAMAM G4 dendrimer as novel nano-complex[J]. Colloids and Surfaces B: Biointerfaces, 2017, 159: Pages 232-240. DOI: 10.1016/j.colsurfb.2017.07.089
[3] KATARZYNA MILOWSKA  Teresa G  Marta Malachowska. PAMAM G4 dendrimers affect the aggregation of α-synuclein[J]. International Journal of Biological Macromolecules, 2011, 48 5: Pages 742-746. DOI: 10.1016/j.ijbiomac.2011.02.021
[4] BING WANG . Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers[J]. International Journal of Pharmaceutics, 2010, 395 1: Pages 298-308. DOI: 10.1016/j.ijpharm.2010.05.030
[5] S. SADEKAR . Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin[J]. International Journal of Pharmaceutics, 2013, 456 1: Pages 175-185. DOI: 10.1016/j.ijpharm.2013.07.071