PEG-SOD

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:

• in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
• as supplement in T cell culture to investigate its effect on cytokine production
• in the preincubation of the carotid artery sections prior to DHE treatment

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.