Magainin 1 (trifluoroacetate salt)

Magainin 1 is a cationic peptide originally isolated from the skin of the African clawed frog (X. laevis) with roles in host defense and antimicrobial activity.1 It reduces germination percentage and mean tube elongation in kiwi fruit pollen (EC50s = 14 and 15.8 µM, respectively).2 Magainin 1 decreases viral replication in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (EC50s = 36.59 and 33.2 µM, respectively) without affecting cell viability (CC50 = >100 µM).3 It induces apoptosis in HL-60 cells when used at concentrations of 10 and 50 µM and hemolysis in isolated human erythrocytes at 50 µM.4 Magainin 1 (10 and 50 µM) induces DNA fragmentation in HL-60 cells in a reporter assay.WARNING This product is not for human or veterinary use.

[1] JÉSSICA M. NASCIMENTO . Evaluation of Magainin I interactions with lipid membranes: An optical and electrochemical study[J]. Chemistry and Physics of Lipids, 2012, 165 5: Pages 537-544. DOI: 10.1016/j.chemphyslip.2012.05.002
[2] A. M. SPERANZA  E. O  A R Taddei. In Vitro Toxicity towards Kiwifruit Pollen of the Antimicrobial Peptides Magainins 1 and 2[J]. Plant Biology, 2008, 9 6: 800-806. DOI: 10.1055/s-2007-965119
[3] VANESA C ALBIOL MATANIC  Viviana C. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus[J]. International Journal of Antimicrobial Agents, 2004, 23 4: Pages 382-389. DOI: 10.1016/j.ijantimicag.2003.07.022
[4] LIDIA CRUZ-CHAMORRO. In vitro biological activities of magainin alone or in combination with nisin[J]. Peptides, 2006, 27 6: Pages 1201-1209. DOI: 10.1016/j.peptides.2005.11.008