eucommiol

Eucommiol is a natural product that can be isolated from the roasted leaves of E. ulmoides. Eucommiol inhibits growth of Molt 4B cells. Eucommiol reduces spontaneous activity and increases the sleep ratio in mice[1][2][3].

ChEBI: Eucommiol is an alicyclic compound that is cyclopent-3-en-1-ol carrying additional hydroxymethyl substituents at positions 3 and 4 as well as a 2-hydroxyethyl substituent at position 2 (the 1R,2R-diastereomer). It has a role as a sedative and a plant metabolite. It is a tetrol, a primary allylic alcohol and an alicyclic compound.

[1] Yumiko ACHIWA, et al. Effect of Eucommiol Isolated from Aucuba (Aucuba japonica Thunb) on the Growth of Human Lymphoid Leukemia Cells. Food Science and Technology Research. 1999, 5 (2), 181-182.
[2] A. Bianco, et al. Structure of eucommiol, a new cyclopentenoid-tetrol from Eucommia Ulmoides. Tetrahedron. 1974, 30 (23-24), 4117-4121.
[3] Li X, et al. Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia. Nat Prod Res. 2013;27(18):1657-9. DOI:10.1080/14786419.2012.746343