次氮基三乙酸-6-异硫氰酸荧光素
次氮基三乙酸-6-异硫氰酸荧光素 性质
| 熔点 | >190° (dec) |
|---|---|
| 沸点 | 747.6±70.0 °C(Predicted) |
| 密度 | 2.23±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.15±0.70(Predicted) |
次氮基三乙酸-6-异硫氰酸荧光素 用途与合成方法
Antibacterial.
Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10 -3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10 -3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA.
