Angiopoietin-1 (ANG-1) is a member of the angiopoietin family of growth factors.1,2 It is composed of a superclustering domain, which mediates oligomerization, a coiled-coil domain, and a fibrinogen-like domain, which facilitates receptor binding. ANG-1 is ubiquitously expressed and forms homomultimers, which are required for activation of its receptors, tunica interna endothelial cell kinase 2 (Tie2) and Tie1. It plays a role in angiogenesis, vascular remodeling and permeability, inflammation, hematopoiesis, and inhibition of apoptosis in endothelial cells. Mutations in ANGPT1, the gene encoding ANG-1, are associated with hereditary angioedema.3 Increased protein levels of ANG-1 correlate with increased levels of Tie2 in patients with colorectal cancer.4 Cayman’s Angiopoietin-1 (human, recombinant) protein is a disulfide-linked homodimer. The reduced monomer, composed of ANG-1 (amino acids 16-261 and 277-498) fused to human IgG1 Fc at its C-terminus, consists of 721 amino acids, has a calculated molecular weight of 82 kDa, and a predicted N-terminus of His16 after signal peptide cleavage.WARNING This product is not for human or veterinary use.
