ATX-001 is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine Delivery.
ATX-001 is an ionizable cationic lipid. ATX-001 can be used in the formation of lipid nanoparticles (LNPs) for the delivery mRNA[1].
ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.
[1] Arcturus Therapeutics, Inc. Preparation of ionizable cationic lipid compounds for RNA delivery. World Intellectual Property Organization, WO2015074085 A1 2015-05-21