Benzoic acid, 3-[[4-(methylamino)-2-quinazolinyl]amino]-

Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.

3-[[4-(Methylamino)-2-quinazolinyl]amino]benzoic Acid is used in the preparation of some molecular binders that targets the SARS-CoV-2 RNA genome, the causative agent of COVID-??19.

Store at -20°C