Liquid. Miscible with water.
The commercial production of isolan involves the synthesis of the pyrazole ring followed by carbamoylation using dimethylcarbamoyl chloride or a similar reagent. The process typically includes condensation of isopropylhydrazine with methyl ethyl ketone to form the substituted pyrazole, which is then esterified with dimethylcarbamic acid derivatives. The final product is purified through distillation or crystallisation.
Colorless liquid. Used as a systemic aphicide in Europe, insecticide. Currently of little commercial interest. Not registered as a pesticide in the U.S.
Isolan powder(content2%-20%) is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Cholinesterase inhibitor.
Extremely toxic carbamate; exhibits acute,delayed and chronic effects similar toorganophosphates; cholinesterase inhibitor;found to be more toxic to rats bydermal than oral route (Merck 1996); toxicsymptoms include trembling, pinpoint pupils,lacrimation, excessive salivation, sweating,slurring of speech, jerky movements, nausea,vomiting, loss of bladder control, slightblueness of skin, lips, and nail beds, aswell as convulsion, and coma (Gosselin et al.1984); death can occur from respiratoryarrest; oral lethal dose in adult humanestimated to be within the range 0.5–2 g.
LD50 oral (rat): 11 mg/kg
LD50 skin (rat): 5.6 mg/kg.
Isolan powder(content2%-20%) is classified as extremely toxic. Probable oral lethal dose in humans is 5-50 mg/kg or between 7 drops and 1 teaspoonful for a 150-lb. person. A cholinesterase inhibitor; although it is not an organic phosphate, it resembles that group in action.
When heated to decomposition, Isolan powder(content2%-20%) emits toxic fumes of nitrogen oxides.
Systemic. Acetylcholinesterase (AchE) inhibitor.
Poison by ingestion,
skin contact, and intraperitoneal routes.
Questionable carcinogen with experimental
tumorigenic data. Mutation data reported.
An insecticide. When heated to
decomposition it emits toxic fumes of NOx.
See also CARBAMATES
