Methyltetrazine-PEG24-amine

Product NameMethyltetrazine-PEG24-amine
CAS2353410-18-9
MF(C2H4O)nC11H13N5O
MW0
EINECS
MOL File2353410-18-9.mol

Chemical Properties

solubility

Soluble in Water, DMSO, DCM, DMF

Usage And Synthesis

Description

Methyltetrazine-PEG24-amine is a monodisperse, click chemistry PEG linker containing a free amine and a methyltetrazine group. It is highly soluble in water. Amine (NH2) is reactive with carboxylic acid containing molecule in the presence of reagnet such as EDC or HATU. Methyltetrazine enable fast click reaction with TCO (trans-cycloctene)

Uses

Methyltetrazine-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005