m-PEG6-SS-PEG6-methyl contains two terminal methoxy groups and a cleavable disulfide bond. The disulfide bond can be cleaved via reduction reactions using Dithiothreitol (DTT) reagent.
m-PEG6-SS-PEG6-methyl is a cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Disulfide Cleavable Linker; Cleavable Linker
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:
10.1038/nrd.2016.268
