Zoniporide hydrochloride hydrate (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED50=0.45 mg/kg/h) in open chest anesthetized rabbits[1].
Zoniporide exhibits moderate plasma protein binding, has a t1/2 of 1.5 hours in monkeys, and has one major active metabolite[1].
Zoniporide hydrochloride hydrate treatment shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively[2].
| Animal Model: | Rabbit[1] |
| Dosage: | 0.25, 1, 4 mg/kg |
| Administration: | Every hour for 2 hours; intravenous injection |
| Result: | Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED50 was 0.45 mg/kg/h. |
| Animal Model: | Rat[2] |
| Dosage: | 1 mg/kg |
| Administration: | Intravenous injection(Pharmacokinetic Analysis) |
| Result: | The AUC0-∞ and t1/2 were 0.07 μg h/mL and 0.5 hours, respectively. |
