PAR3 (1-6) amide (human) (trifluoroacetate salt)

PAR3 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) and PAR2 that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) amide activates PAR1 and PAR2 in Jurkat and HEK cells, inducing calcium accumulation in Jurkat cells, which is reduced following desensitization with the PAR1- and PAR2-selective peptide agonist SFLLR-NH2.1 It decreases the expression of CDC42 in wild-type, but not PAR3 knockdown, PANC-1 cells and reduces invasion of PANC-1 cells.2WARNING This product is not for human or veterinary use.

[1] KRISTINA K. HANSEN  Morley D H  Mahmoud Saifeddine. Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells[J]. Immunology, 2004, 112 2: 183-190. DOI: 10.1111/j.1365-2567.2004.01870.x
[2] LIORA SEGAL. Proteinase-activated receptors differentially modulate in vitro invasion of human pancreatic adenocarcinoma PANC-1 cells in correlation with changes in the expression of CDC42 protein.[J]. Pancreas, 2014, 43 1: 103-108. DOI: 10.1097/mpa.0b013e31829f0b81