Fatty acid desaturase 1 (FADS1), also known as Δ5 desaturase, is a 444-amino acid transmembrane protein encoded by FADS1.1 It catalyzes conversion of dihomo-γ-linolenic acid (Item No. 90230) to arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and ω-3 arachidonic acid (Item No. 90011) to eicosapentaenoic acid (Item Nos. 90110 | 90110.1 | 21908) during the production of ω-6 and ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs), respectively. Hepatic FADS1 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH).2 Tissue-selective knockdown of Fads1 in the liver, adipose tissue, and reticuloendothelial system of adult hyperlipidemic LDL receptor-null mice promotes hepatic inflammation and formation of atherosclerotic plaques and suppresses hepatic lipogenesis.3 Increased expression of FADS1 positively correlates with disease-free survival and overall survival times in patients with esophageal squamous cell carcinoma (ESCC).4 Cayman's Fatty Acid Desaturase 1 Monoclonal Antibody (Clone 3A10.1) can be used for immunoprecipitation (IP), ELISA, and Western blot (WB) applications. The antibody recognizes FADS1 at approximately 45 kDa from human samples.WARNING This product is not for human or veterinary use.
