Diethyl (2-methylallyl)phosphonate can be used as a reagent in the Horner-Wadsworth-Emmons reaction to form conjugated carbon–carbon double bonds.
It can also be used as a reactant for:
- Enantioselective total synthesis of 10-isocyano-4-cadinene as antifouling agent.
- Regiospecific preparation of 4-oxo-2-alkenylphosphonates (OAP) via silylation followed by Friedel-Crafts acylation and isomerization. OAP can serve as building blocks for the construction of polyethylenic chains.
- The synthesis of azaphosphone as a potent analgesic/anti-inflammatory agents.
