BMS-248360
中文名称:BMS-248360
英文名称:BMS-248360
CAS号:254737-87-6
分子式:C36H45N5O5S
分子量:659.84
EINECS号:
Mol文件:254737-87-6.mol
BMS-248360 用途与合成方法
BMS-248360 是一种高效、有口服活性的血管紧张素 II 受体 (AT1) 和内皮素 A (ETA) 受体双拮抗剂,对 hAT1 和 hETA 受体作用的 Ki 值分别为 10 nM 和 1.9 nM。BMS-248360 具有抗高血压作用。
Ki: 10 nM (hAT1), 1.9 nM (hETA receptor), 6.0 nM (rAT1), 1.9 nM(r ET A receptor)
BMS-248360 shows activity against rat AT1 and rat ET
A
receptor, with K
i
s of 6.0 nM and 1.9 nM, respectively.
BMS-248360 shows no activity against AT2 and ET
B
receptor subtypes.
BMS-248360 is found to be orally bioavailable in rats (%F=38) with excellent oral exposure (C
max
)=3.1 µM) and reasonable elimination profile (T
1/2
=5.5 hours).
BMS-248360 (30 µmol/kg, 100 µmol/kg; p.o.) blocks the hypertensive effects of intravenously administered AII.
Animal Model: | Male Rats |
Dosage: | 30 µM/kg, 100 µM/kg |
Administration: | Oral administration |
Result: | Blocked the hypertensive effects of intravenously administered AII. |
Animal Model: | Male Rats |
Dosage: | 10 µM/kg |
Administration: | Oral administration |
Result: | T 1/2 = 5.5 hours |
BMS-248360供应商 更多
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:BMS-248360
CAS:254737-87-6
包装信息:100mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 T14672
英文名称:BMS-248360;BMS 248360,BMS248360
CAS:254737-87-6
纯度:98%
包装信息:5 mg