Sulfo-Cy5 alkyne is a water soluble cyanine linker containing an alkyne group, which enables Click Chemistry to attach the deeply colored and photostable Cyanine5 fluorophore to various azide-bearing molecules. Sulfo-Cyanine5 is a sulfonated dye with high hydrophilicity and aqueous solubility, high extinction coefficient, good quantum yield, and compatibility with many instruments. This reagent is recommended for conjugation with proteins, nanoparticles, and other applications where hydrophilicity is important.