(2-pyridyldithio)-PEG4-alcohol

(2-pyridyldithio)-PEG2-alcohol is a PEG linker which contains a pyridyl disulfide moiety and an alcohol group. The pyridyl disulfide group can react with thiol groups of proteins over a wide range of pH level. The hydroxyl group allows for further derivatization of the compound. The hydrophilic PEG linker increases the water solubility of the compound.

(2-Pyridyldithio)-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005