CARBACYCLIN
CARBACYCLIN 性质
| 熔点 | 65-67℃ |
|---|---|
| 沸点 | 514.8±50.0 °C(Predicted) |
| 密度 | 1.177±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 在乙醇中溶解度为 20mg/ml。 |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.77±0.10(Predicted) |
| 颜色 | 白色至米白色 |
CARBACYCLIN 用途与合成方法
|
PGI 2 Receptor
|
Carbacyclin is an agonist of prostacyclin (PGI2) receptor. Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro. Carbacyclin is a PGI2 analogue, activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes.
Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, dog or rabbit plasma. Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression in murine heart.
CARBACYCLIN 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-02-05 | HY-112322 | CARBACYCLIN | 69552-46-1 | 100 μg (2.85 mM * 100 μL in Methyl acetate) | 2250 |
| 2025-02-05 | HY-112322 | CARBACYCLIN | 69552-46-1 | 500 μg (2.85 mM * 500 μL in Methyl acetate) | 3900 |
