BTSA 1

Product NameBTSA 1
CAS314761-14-3
MFC21H14N6OS2
MW430.51
EINECS
MOL File314761-14-3.mol

Chemical Properties

Boiling point	625.2±48.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM)
pka	6.52±0.40(Predicted)
form	Solid
color	Brown to reddish brown

Usage And Synthesis

Biological Activity

BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells.

in vivo

BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated.

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