Propargyl-PEG5-CH2CO2-NHS

Product NamePropargyl-PEG5-CH2CO2-NHS
CAS1161883-51-7
MFC17H25NO9
MW387.38
EINECS
MOL File1161883-51-7.mol

Chemical Properties

storage temp.	Storage temp. -20°C
solubility	Soluble in DMSO, DCM, DMF
form	Viscous Liquid
color	Colorless to light brown

Usage And Synthesis

Description

Propargyl-PEG5-CH2CO2-NHS is an amine reactive linker with an alkyne moeity which can react with azide-bearing biomolecules in copper catalyzed Click Chemistry reactions. The PEG units enhance the solubility of the linker in aqueous media.

Uses

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] Kussrow A, et al. Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scatteringinterferometry. Anal Chem. 2009 Jun 15;81(12):4889-97. DOI:10.1021/ac900569c