DSR 6434 (cas# 1059070-10-8) is a useful research chemical.DSR is a TLR7 agonist. DSR 6434 indicated an optimal balance between the agonistic potency and high water solubility.
DSR 6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist with EC50 of 7.2 nM and 4.6 nM for human and mouse TLR7, respectively. It has strong antitumor effect.
To assess the specificity of DSR-6434 toward TLR7, an NF-κB-driven reporter assay is performed in HEK293 cells engineered to express either hTLR7, TLR8 or TLR9. In this assay, successful binding of DSR-6434 to the specific receptor leads to NF-κB activation.
| TLR7 7.2 nM (EC 50 , Human) | TLR7 4.6 nM (EC 50 , Mice) |
