(+)-DHMEQ is an activator of the antioxidant transcription factor Nrf2. It is the enantiomer of (-)-DHMEQ. And it inhibited NF-kB activity less than (-)-DHMEQ.
in vitro
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay.
