GB83 is a serum stable, potent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 μM) th at reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices
