Bromo-PEG2-phosphonic acid is a PEG linker containing bromine and phosphonic acid moieties. The bromine group is a good leaving group and participates in substiution reactions. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
Uses
Bromo-PEG2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
