IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1; IC50s = 290 and 98 nM for the human recombinant enzyme in a cell-free assay and in HeLa cells, respectively).
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.
IDO: 290 nM (IC50); IDO: 98 nM (IC50, in HeLa cell)
[1] Yue EW, et al. INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett. 2017 Mar 6;8(5):486-491. DOI:
10.1021/acsmedchemlett.6b00391
