PIRONETIN
PIRONETIN 性质
| 熔点 | 75-77 °C |
|---|---|
| 沸点 | 473.1±40.0 °C(Predicted) |
| 密度 | 0.993±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二氯甲烷：可溶； DMSO：可溶；乙醇：可溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.28±0.20(Predicted) |
| 颜色 | 无色至类白色 |
PIRONETIN 用途与合成方法
雄小鼠急性经口 LD500325mg/kg。Ames试验呈阴性。
Pironetin 是从链霉菌属物种分离的 α/β 不饱和内酯。Pironetin 与 α-tubulin 结合，是微管聚合的有效抑制剂，具有细胞周期停滞和抗肿瘤活性。Microtubule
Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells.
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation.
IC
50
values against these cell lines are almost 10 ng/mL.
Cell Cycle Analysis
| Cell Line: | 3Y1 cells |
| Concentration: | 20 ng/mL, 50 ng/mL, 100 ng/mL |
| Incubation Time: | 24 hours |
| Result: | Arrested the cell cycle progression at G2/M in3Y1 cells. |
Cell Proliferation Assay
| Cell Line: | HeLa, A2780 and K-NRK cells |
| Concentration: | 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL |
| Incubation Time: | 3 days |
| Result: | Inhibited the cell proliferation. |
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect.
| Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells |
| Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 5 days |
| Result: | Showed a moderate antitumor effect. |
水稻以100g/10公亩剂量处理水稻，对其地面部分抑制程度为18%～23%，以25g/10公亩剂量处理，则对地面部分几乎无抑制作用，在出穗前5～9d施用pironetin对产量无影响。小麦用125~1000mg/L的喷洒浓度处理旱田小麦，对株高呈现20%左右的生长抑制活性，但对小麦穗数并无影响。以2000mg/L处理对小麦有药害，平均每穗重及千粒重减少10%左右。
以5-甲基-2-庚烯为原料经以下步骤合成：
PIRONETIN 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-116446 | PIRONETIN | 151519-02-7 | 500 μg | 4740 |
| 2024-11-08 | HY-116446 | PIRONETIN | 151519-02-7 | 1mg | 8800 |
