PIRONETIN
中文名称:PIRONETIN
英文名称:PIRONETIN
CAS号:151519-02-7
分子式:C19H32O4
分子量:324.45
EINECS号:
Mol文件:151519-02-7.mol
![PIRONETIN 结构式](https://img.chemicalbook.com/CAS/GIF/151519-02-7.gif)
PIRONETIN 性质
熔点 | 75-77 °C |
---|---|
沸点 | 473.1±40.0 °C(Predicted) |
密度 | 0.993±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二氯甲烷:可溶; DMSO:可溶;乙醇:可溶 |
形态 | 固体 |
酸度系数(pKa) | 14.28±0.20(Predicted) |
PIRONETIN 用途与合成方法
Pironetin 是从链霉菌属物种分离的 α/β 不饱和内酯。Pironetin 与 α-tubulin 结合,是微管聚合的有效抑制剂,具有细胞周期停滞和抗肿瘤活性。
Microtubule
Pironetin (20-100 ng/mL; 24 hours; 3Y1 cells) treatment arrests the cell cycle progression at G2/M in 3Y1 cells.
Pironetin (1-10000 ng/mL; 3 days; HeLa, A2780 and K-NRK cells) treatment inhibits the cell proliferation.
IC
50
values against these cell lines are almost 10 ng/mL.
Cell Cycle Analysis
Cell Line: | 3Y1 cells |
Concentration: | 20 ng/mL, 50 ng/mL, 100 ng/mL |
Incubation Time: | 24 hours |
Result: | Arrested the cell cycle progression at G2/M in3Y1 cells. |
Cell Proliferation Assay
Cell Line: | HeLa, A2780 and K-NRK cells |
Concentration: | 1 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL and 10000 ng/mL |
Incubation Time: | 3 days |
Result: | Inhibited the cell proliferation. |
Pironetin (0.78-6.25 mg/kg; intraperitoneal injection; daily; for 5 days; female CDF1-SLC mice) treatment shows a moderate antitumor effect, however, a severe weight loss is observed as a side effect.
Animal Model: | Female CDF1-SLC mice (10 weeks) injected with P388 murine leukemia cells |
Dosage: | 0.78 mg/kg, 1.56 mg/kg, 3.13 mg/kg, 6.25 mg/kg |
Administration: | Intraperitoneal injection; daily; for 5 days |
Result: | Showed a moderate antitumor effect. |
PIRONETIN供应商 更多
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Pironetin
CAS:151519-02-7
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
英文名称:Pironetin
CAS:151519-02-7
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:Pironetin
CAS:151519-02-7
纯度:70%
包装信息:1mg
备注:试剂级
銳迪國際科技有限公司
联系电话: 18024082417
产品介绍:
英文名称:Pironetin
CAS:151519-02-7
纯度:5mg;10mg;50mg;100mg;250mg;500mg;1g
包装信息:5mg;10mg;50mg;100mg;250mg;500mg;1g