4-(4-(Dimethylamino)styryl)-N-methylpyridinium iodide

Product Name4-(4-(Dimethylamino)styryl)-N-methylpyridinium iodide
CAS959-81-9
MFC16H19N2.I
MW366.24
EINECS
MOL File959-81-9.mol

Chemical Properties

Melting point	261–262℃
solubility	Soluble in methanol, N,N-dimethylformamide
form	Solid
pka	3.1(Temp: 25 °C; Solvent: Water)
color	Greenish purple solid;2 Purple solid; Red needles
Appearance	Solid Powder
λmax	475 nm
Major Application	Electrochromic materials;glass;nonlinear optical (NLO) materials;photoconductors;thin films
Biological Applications	Detecting nucleic acids,prostate cancer; treating amyloidosis disorders,bacterial infection

Usage And Synthesis

Description

4-(4-(dimethylamino)styryl)-n-methylpyridinium iodide is utilized in the biomedical industry as a fluorescent probe that specifically stains mitochondria. It is commonly used to study mitochondrial function, localization, and dynamics in various cell types. Additionally, this compound aids in investigating diseases associated with mitochondrial dysfunction such as neurodegenerative disorders and cancer.

Uses

4-Di-1-ASP is a styryl dye used to stain glioma cells in living brain tissue for analysis of cell structure, viability, proliferation and endocytosis, cytokinesis and phagocytosis, as well as for observation of mitochondrial structures in living cells. 4-Di-1-ASP fluoresces green when imaged microscopically (λex /λem = 475/606 nm) [1][2].

Definition

ChEBI: 4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide is an organic iodide salt consisting of pyridinium iodide having a methyl substituent at the 1-position and a 4-dimethylaminostyryl substituent at the 4-position. It has a role as a fluorochrome. It is an organic iodide salt and a pyridinium salt. It contains a 4-[4-(dimethylamino)styryl]-N-methylpyridinium.

References

[1] Lilia Y Kucheryavykh, et al. Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+). Biotechniques. 2012 Nov;53(5):305-9. DOI:10.2144/000113940
[2] Jensen J H Wong, et al. Simultaneous High-Throughput Conformational and Colloidal Stability Screening Using a Fluorescent Molecular Rotor Dye, 4-(4-(Dimethylamino)styryl)-N-Methylpyridinium Iodide (DASPMI). J Biomol Screen. 2016 Sep;21(8):842-50. DOI:10.1177/1087057116646553

Excitation / Emission Maximum

340 nm/488 nm

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