[1,1'-Biphenyl]-4-carboxaMide, N-[1-(4-chlorophenyl)-3-(diMethylaMino)propyl]-

FL104 is a novel and potent small-molecule urotensin II receptor agonist.

FL104 is a potent small molecule urotensin II receptor agonist with pEC50 of 7.11 for UTII receptor in R-SATTM assay[1][2].

[1] Lehmann F, et al. Novel and potent small-molecule urotensin II receptor agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4657-65. DOI:10.1016/j.bmc.2009.04.062
[2] Lehmann F, et al. Design, parallel synthesis and SAR of novel urotensin II receptor agonists. Eur J Med Chem. 2007 Feb;42(2):276-85. DOI:10.1016/j.ejmech.2006.09.015