D-myo-Inositol-3-phosphate (sodium salt)

D-myo-Inositol-3-phosphate (Ins(3)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(3)P1 can be formed by the dephosphorylation of polyphosphate inositols such as Ins(3,4)P2 by inositol polyphosphate 4-phosphatase.1WARNING This product is not for human or veterinary use.

[1] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI: 10.1146/annurev.bi.61.070192.001301
[2] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI: 10.1038/361315a0
[3] H. STREB. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate[J]. Nature, 1983, 306 5938: 67-69. DOI: 10.1038/306067a0
[4] Y YOSHIDA  S I. Structure and function of inositol 1,4,5-trisphosphate receptor.[J]. Japanese journal of pharmacology, 1997, 74 2: 125-137. DOI: 10.1254/jjp.74.125
[5] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI: 10.1146/annurev.pa.36.040196.002405