5-Acetoxymethyl-2''-deoxyuridine can be used for a method is described for the solid-?phase synthesis of oligonucleotides containing the DNA oxidation damage product, 5-?(hydroxymetyl)?-?2''-?deoxyuridine (HMdU) at selected sites using a phosphoramidite synthon regiospecifically protected on the 5-?(hydroxymethyl) group.
