1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride

Pale Yellow Solid

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

PKG: 4 μM (IC₅₀); PKA: 8 μM (IC₅₀); PKC: 12 μM (IC₅₀); MLCK: 240 μM (IC₅₀); ROCK

[1] Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. PMID:2955213
[2] Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. DOI:10.1371/journal.pone.0017557