MADD (MAP kinase-activating death domain protein) prevents apoptosis and induces human lung adenocarcinoma. It has the ability to bind to the death domain of TNFR1 (tumor necrosis factor receptor 1). MADD can activate TNF-α gene expression and also has the capability to promote the JNK (c-Jun NH2-terminal kinase) pathway. It modulates the recycling of Rab3 small G proteins and plays a major role in Ca2+-dependent neurotransmitter release and exocytosis. This protein also participates in inhibiting the apoptosis of neuronal cells.
