AM 404

AM-404 (198022-70-7) inhibits anandamide transport (IC50= 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2Vanilloid receptors are activated by AM-404.3Activein vivo.1

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).

[1] ANTONIO CALIGNANO . Potentiation of anandamide hypotension by the transport inhibitor, AM404[J]. European journal of pharmacology, 1997, 337 1: Pages R1-R2. DOI:10.1016/s0014-2999(97)01297-1
[2] M. BELTRAMO. Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition[J]. Science, 1997, 277 5329. DOI:10.1126/science.277.5329.1094
[3] PETER M ZYGMUNT . The anandamide transport inhibitor AM404 activates vanilloid receptors[J]. European journal of pharmacology, 2000, 396 1: Pages 39-42. DOI:10.1016/s0014-2999(00)00207-7