Oxidized phospholipids (OxPLs) are a class of lipid mediators involved in diverse physiological and pathological processes.1 In particular, fragmented OxPLs on the surface of LDL can be formed via β-scission of the sn-2 fatty acid fragment on the glycerol backbone and are immunogenic.1,2 The 509 OxPL antibody clone binds to oxidized LDL (OxLDL) and selectively binds to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine (OxPAPE) over PAPE, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC), PAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoserine (OxPAPS), PAPS, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidic acid (OxPAPA), and PAPA.3 Cayman’s Oxidized Phospholipid Monoclonal Antibody (Clone 509) can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. The original 509 antibody was generated via immunization of mice with OxPAPC and oxLDL with Freund’s adjuvant.3WARNING This product is not for human or veterinary use.
