Isoguanosine-5'-O-triphosphate (sodium salt)

Isoguanosine-5'-O-triphosphate is an isomer of guanosine 5'-triphosphate (GTP; Item No. 16060) and a phosphorylated form of crotonoside (Item No. 28219). Unlike GTP, isoguanosine-5'-O-triphosphate does not stimulate microtubule assembly.1 Isoguanosine-5'-O-triphosphate (2 mM) inhibits transcription and induces T to C mutations in a reverse transcriptase assay.2 It has been used to determine the substrate specificity of phosphofructokinase and mutT homolog 1 (MTH1).3,4WARNING This product is not for human or veterinary use.

[1] M MURAOKA. The effects of various GTP analogues on microtubule assembly.[J]. Cell structure and function, 1999, 24 2: 101-109. DOI: 10.1247/csf.24.101
[2] HIROYUKI KAMIYA. Mutagenic properties of oxidized GTP and ATP in in vitro transcription-reverse transcription.[J]. Nucleic acids symposium series (2004), 2006, 50: 99-100. DOI: 10.1093/nass/nrl049
[3] O. BÂRZU. Specificity of rabbit muscle phosphofructokinase for nucleotides as substrates or as allosteric effectors[J]. Archives of biochemistry and biophysics, 1977, 182 1: Pages 42-51. DOI: 10.1016/0003-9861(77)90281-8
[4] K FUJIKAWA. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.[J]. Nucleic Acids Research, 2001, 29 2: 449-454. DOI: 10.1093/nar/29.2.449