BMP2-derived Peptide (trifluoroacetate salt)

BMP2-derived peptide is a synthetic peptide that corresponds to residues 73-92 of bone morphogenetic protein 2 (BMP2) and has a role in osteogenesis.1 It increases alkaline phosphatase (ALP) activity in C3H/10T1/2 murine mesenchymal cells when used at concentrations of 100 and 200 µg/well. BMP2-derived peptide (100 µg/well) increases mRNA expression of the gene encoding osteocalcin in C3H/10T1/2 cells. It induces osteoblast-like cell differentiation and ectopic calcification when conjugated to an alginate gel in rats when administered via a submuscular implant.2WARNING This product is not for human or veterinary use.

[1] ATSUHIRO SAITO . Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope[J]. Biochimica et biophysica acta. Proteins and proteomics, 2003, 1651 1: Pages 60-67. DOI: 10.1016/s1570-9639(03)00235-8
[2] ATSUHIRO SAITO. Prolonged ectopic calcification induced by BMP-2–derived synthetic peptide[J]. Journal of biomedical materials research. Part A, 2004, 70A 1: 115-121. DOI: 10.1002/jbm.a.30071