[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide is an agonist of the neuropeptide Y (NPY) receptor Y5.1 It inhibits cAMP production induced by forskolin (Item No. 11018) in HEK293 cells expressing the human Y5 receptor (EC50 = 17 nM). [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide selectively binds to Y5 (IC50 = 0.24 nM in HEK293 cells expressing the human receptor) over Y1, Y2, and Y4 (IC50s = 530, >500, and 51 nM, respectively, in BHK-21 cells expressing the human receptors). In vitro, [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide increases VEGF levels, as well as endothelial branch length and the number of branch points, in 4T1 murine mammary carcinoma cells in a concentration-dependent manner.2 It induces relaxation of vasopressin-precontracted rat mesenteric arteries when used at a concentration of 1 µM.3 Intracranial administration of [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - pancreatic polypeptide (0.2 and 2 nmol/animal) increases food intake in rats.1WARNING This product is not for human or veterinary use.
[1] C CABRELE. The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats.[J]. The Journal of Biological Chemistry, 2000, 275 46: 36043-36048. DOI:
10.1074/jbc.m000626200[2] PHILIP J. MEDEIROS Dwayne N J. Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis[J]. Peptides, 2013, 48: Pages 106-113. DOI:
10.1016/j.peptides.2013.07.029[3] KATHRYN A. GRADIN . Blunted pancreatic polypeptide-induced vasodilatation in mesenteric resistance vessels from spontaneously hypertensive rats[J]. European journal of pharmacology, 2008, 601 1: Pages 118-123. DOI:
10.1016/j.ejphar.2008.09.037
