Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].
Tested on uterine cervical (UI4) and sarcoma 180 (S180) tumors in mice, the furanodienehas a significant tumor inhibition rate dose-dependent. The furanodienewas administered intraperitoneally as liposome. The effect of furanodiene on theinhibition of cell proliferation by activation of apoptosis was not hypothesized(Song et al. 2014, Zielińska and Matkowski 2014, Polo et al. 2013).
