9-Octadecenoic acid, 9-nitro-, (9E)-, (9E)-10-nitro-9-octadecenoate (1:1)

9(10)-Nitrooleate (9(10)-Nitrated oleic acid) is a nitrated derivative of Oleic acid (HY-N1446). 9(10)-Nitrooleate can activate PPAR (PPARα, PPARβ/δ, and PPARγ), promoting fat formation and glucose uptake, inhibiting the function of neutrophils and platelets, and can be used in lipid metabolism and inflammation research[1].

PPARα; PPARγ; PPARβ/δ

[1] Francisco J Schopfer, et al. Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor. J Biol Chem. 2005 May 13;280(19):19289-97. DOI:10.1074/jbc.M414689200
[2] PAUL R S BAKER. Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands.[J]. The Journal of Biological Chemistry, 2005, 280 51: 42464-42475. DOI: 10.1074/jbc.m504212200
[3] DARCY J. P. BATES. Nitroalkene Fatty Acids Mediate Activation of Nrf2/ARE-Dependent and PPARγ-Dependent Transcription by Distinct Signaling Pathways and with Significantly Different Potencies[J]. Biochemistry Biochemistry, 2011, 50 36: 7765-7773. DOI: 10.1021/bi2005784
[4] HAIYING LIU. Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury.[J]. American Journal of Physiology-renal Physiology, 2008, 295 4: F942-9. DOI: 10.1152/ajprenal.90236.2008