Ac-Asp-Met-Gln-Asp-PNA

Ac-DMQD-pNA is a peptide substrate. Both of the recombinant CgCaspase-1 (rCgCaspase-1) and the C-terminus of CgCaspase-1 (rCgCaspase-1-C) exhibits similar caspase activity towards proteolytic substrate Ac-DMQD-pNA and Ac-DEVD-pNA (HY-P1006)[1][2].

[1] Fang B, et al. Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition. J Mol Biol. 2006 Jul 14;360(3):654-66. DOI:10.1016/j.jmb.2006.05.041
[2] Lu G, et al. The self-activation and LPS binding activity of executioner caspase-1 in oyster Crassostrea gigas. Dev Comp Immunol. 2017 Dec;77:330-339. DOI:10.1016/j.dci.2017.09.002