5-hydroxyeicosatetraenoic acid lactone

(±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation[1][2].

[1] Tao C, et al. Reactivity of tricarbonyl (pentadienyl) iron (1+) cations: enantioselective synthesis of 5-HETE methyl ester[J]. The Journal of Organic Chemistry, 1993, 58(8): 2134-2143.
[2] Picardo C M. The hydrolysis of 5-HETE lactone by paraoxonase 1 and its stability in serum[M]. 2007.
[3] F. A. J. KERDESKY. ChemInform Abstract: Synthesis and 5-Lipoxygenase Inhibitory Activity of 5-Hydroperoxy- 6,8,11,14-eicosatetraenoic Acid Analogues.[J]. ChemInform, 1987, 18 50. DOI: 10.1002/chin.198750355