136174-04-4
中文名称:136174-04-4
英文名称:N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide
CAS号:136174-04-4
分子式:C20H25ClN2O2
分子量:360.88
EINECS号:
Mol文件:136174-04-4.mol
136174-04-4 性质
| 沸点 | 462.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.83±0.20(Predicted) |
136174-04-4 用途与合成方法
RG-12915 是一种选择性的 5-HT3 拮抗剂，IC50 值为 0.16 nM。
|
5-HT 3 Receptor 0.16 nM (IC 50 ) |
RG 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites (IC 50 value = 0.16 nM), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC 50 values less than 1 μM.
RG 12915 has a lower ED 50 value (0.004 mg/kg) for attenuating cisplatin-induced emetic episodes in the ferret. RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species.
136174-04-4供应商 更多
成都超九八生物科技有限公司
联系电话：13348960310 13348960310
产品介绍：
英文名称：RG-12915
CAS：136174-04-4
纯度：98%
包装信息：5mg；10mg；20mg；50mg；100mg；200mg
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223;
产品介绍：
英文名称：RG-12915
CAS：136174-04-4
包装信息：100mg
备注： 试剂级
