(5Z,8R,9R,10E,12S)-8-acetyl-9-formyl-12-hydroxyheptadeca-5,10-dienoic acid

Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide; gamma-ketoaldehyde cpd; related to prostaglandin E2.

ChEBI: Levuglandin E2 is a levuglandin.

Levuglandin E2 (LGE2), a rearrangement product derived from the prostaglandin endoperoxide, PGH2, causes repair-resistant DNA-protein cross-links and cell death (LD50 = 230 nM) in V79 Chinese hamster lung fibroblasts._x000D_ _x000D_ Reference: Biochemistry. 1993 Apr 20;32(15):4090-7. https://pubmed.ncbi.nlm.nih.gov/8471616/

Treatment of LDL with LGE2 (Levuglandin E2) leads to uptake and degradation by mouse peritoneal macrophages. Oxidized LDL, but not acetyl LDL efficiently competed for binding and uptake of LGE2-modified 125I-LDL. This result suggests that LGE2-modified LDL was recognized by a class of scavenger receptor that demonstrated ligand specificity for oxidized LDL but not for acetyl LDL._x000D_ _x000D_ Reference: Biochim Biophys Acta. 1997 Jan 7;1344(1):1-5. https://pubmed.ncbi.nlm.nih.gov/9022751/

Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide.