10-Oxo-12(Z),15(Z)-octadecadienoic acid is a gut microbial fatty acid metabolite[1].
10-oxo-12(Z),15(Z)-Octadecadienoic acid is an oxylipin. It is produced from α-linolenic acid by the gut bacteria L. plantarum.1 10-oxo-12(Z),15(Z)-Octadecadienoic acid decreases increases in mRNA expression levels of the gene encoding SREBP-1c by the liver X receptor (LXR) agonist T0901317 in HepG2 cells.
1.Nanthirudjanar, T., Furumoto, H., Zheng, J., et al.Gut microbial fatty acid metabolites reduce triacylglycerol levels in hepatocytesLipids50(11)1093-1102(2015)
