Deoxyfusapyrone is an α-pyrone fungal metabolite originally isolated from F. semitectum and has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses (MICs = 1.56-6.25 μg/ml). Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium, in a disc assay.
Deoxyfusapyrone is a broad spectrum antifungal metabolite isolated from several Fusarium species, first reported in 1994. Deoxyfusapyrone exhibits low zoo-toxicity as evidenced by a lack of toxicity against Artemia salina and is a useful candidate for control of postharvest crop diseases. Like the related fusapyrone, its mechanism of action is unknown and its structure was revised in 2006.
